If you buy any medicines, please check with your doctor or a pharmacist that they are suitable for you to take with dapoxetine. If you have any problems with the way your liver works, or if you have any problems with the way your kidneys work. The first contemporary multivariate evidence-based definition of lifelong PE was developed in by a panel of international experts, convened by the International Society for Sexual Medicine ISSM , who agreed that the diagnostic criteria necessary to define PE are time from penetration to ejaculation, inability to delay ejaculation and negative personal consequences from PE. If you are taking any other medicines. Ans : Dapoxetine is used to cure premature ejaculation in men between 18 and 64 years of age. Ans : Please consult your doctor if you are experiencing erectile dysfunction during the course of medication with Dapoxetine. Dapoxetine is not recommended in men with severe renal impairment, and caution is advised in men with mild to moderate renal impairment.Dapoxetine is prescribed for the treatment of premature ejaculation. Take one tablet hours before you have sex. The most common side-effects include feeling dizzy or faint, and feeling sick (nausea). Drinking a full glass of water at the same time as taking the tablet can reduce these effects. Development and regulatory approval of drugs specifically for the treatment of PE will reduce reliance on off-label treatments and serve to fill an unmet treatment need. The objective of this article is to review evidence supporting the efficacy and safety of dapoxetine in the treatment of PE. Dapoxetine is a selective serotonin reuptake inhibitor, structurally related to fluoxetine, which was initially being developed by Eli Lilly for the potential treatment of depression, for which it was in phase I trials; however, no development regarding this indication has been reported after