It contains the ingredient alprostadil, a natural prostaglandin. Its effects might last longer if you have mild to moderate ED. That said, some studies have shown that ED creams may be an effective treatment option in the future, particularly when they contain the ingredient alprostadil. The products discussed in this site may have different product labeling in different countries. It lasts 4 to 5 hours, or longer if you have mild to moderate ED. If you prefer, you may contact the U.MED, a new gel sold as Eroxon, has been approved for marketing by the Food and Drug Ad ministration (FDA) to treat erectile dysfunction. Eroxon received a “de novo” classification by the FDA. Erectile dysfunction affects an estimated 18 million men in the U.S. alone. Here you’ll find impotence information including its causes, impotence drugs, and other promising treatments for ED. Topical creams for erectile dysfunction aim to increase blood flow to the area by widening the blood vessels within the penis. A person will apply these creams directly to the penis before sex.